Generation of two human iPSC lines with Exon 3 mutations in BCL2-Associated Athanogene 3 (BAG3) from dilated cardiomyopathy patients

Generation of two human iPSC lines with Exon 3 mutations in BCL2-Associated Athanogene 3 (BAG3) from dilated cardiomyopathy patients

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Dilated cardiomyopathies (DCM) are one el reformador tequila anejo of the main causes of heart failure as one ages.BAG3 is a chaperone protein that is heavily implicated in the development of DCM and speed of progression toward heart failure.Here we generate two human iPSC lines from individuals with mutations in exon 3 of BAG3 and provide validation of their pluripotency and ability to differentiate toward the three primary germ layers.These two cell lines can help alphaville clothing our understanding of BAG3 and its role in DCM by providing a good model for BAG3 inactivation and insufficiency.